Pharmacokinetic-Pharmacodynamic Modeling of the Electroencephalogram Effect of Imipenem in Healthy Rats

A pharmacokinetic-pharmacodynamic (PK-PD) modeling approach was developed to investigate the epileptogenic activity of imipenem in rats. Initially, animals received an intravenous infusion of imipenem at a rate of 2.65 mg min(−1) for 30 min. Blood samples were collected for drug assay, and an electr...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Dupuis, Antoine, Couet, William, Paquereau, Joël, Debarre, Stanley, Portron, Agnès, Jamois, Candice, Bouquet, Serge
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2001
Assuntos:	Pharmacology
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90531/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11353611/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.6.1682-1687.2001
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