Pharmacokinetic-Pharmacodynamic Modeling of the Electroencephalogram Effect of Norfloxacin in Rats

A previously developed pharmacokinetic-pharmacodynamic (PK-PD) modeling approach was used to investigate the epileptogenic activity of norfloxacin as a representative antibiotic with concentration-dependent antimicrobial activity. Rats received an intravenous infusion of norfloxacin at a rate of 5 m...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Chenel, Marylore, Barbot, Agnès, Dupuis, Antoine, Mimoz, Olivier, Paquereau, Joël, Bouquet, Serge, Couet, William
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2003
Schlagworte:	Experimental Therapeutics
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC155845/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12760873/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.6.1952-1957.2003
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