Norfloxacin-Induced Electroencephalogram Alteration and Seizures in Rats Are Not Triggered by Enhanced Levels of Intracerebral Glutamate

Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram (EEG) effect was combined with intracerebral glutamate determinations using microdialysis for rats receiving norfloxacin intravenously (150 mg/kg of body weight). The EEG effect (accompanied by tremors and seizures) was consistentl...

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Detalhes bibliográficos
Main Authors: Chenel, Marylore, Limosin, Anne, Marchand, Sandrine, Paquereau, Joël, Mimoz, Olivier, Couet, William
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC253770/
https://ncbi.nlm.nih.gov/pubmed/14576142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.11.3660-3662.2003
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