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Pharmacokinetic-Pharmacodynamic Modeling of the Electroencephalogram Effect of Norfloxacin in Rats

A previously developed pharmacokinetic-pharmacodynamic (PK-PD) modeling approach was used to investigate the epileptogenic activity of norfloxacin as a representative antibiotic with concentration-dependent antimicrobial activity. Rats received an intravenous infusion of norfloxacin at a rate of 5 m...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Chenel, Marylore, Barbot, Agnès, Dupuis, Antoine, Mimoz, Olivier, Paquereau, Joël, Bouquet, Serge, Couet, William
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2003
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC155845/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12760873/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.6.1952-1957.2003
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