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Norfloxacin Blood-Brain Barrier Transport in Rats Is Not Affected by Probenecid Coadministration
The effect of probenecid (PRO) on norfloxacin (NOR) blood-brain barrier transport was investigated with rats by microdialysis. Maximum brain drug concentrations were rapidly attained, and the brain penetration factor was close to 5% in the absence and presence of PRO. In conclusion, PRO has no effec...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Microbiology
2006
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1346768/ https://ncbi.nlm.nih.gov/pubmed/16377715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.1.371-373.2006 |
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