Norfloxacin Blood-Brain Barrier Transport in Rats Is Not Affected by Probenecid Coadministration

The effect of probenecid (PRO) on norfloxacin (NOR) blood-brain barrier transport was investigated with rats by microdialysis. Maximum brain drug concentrations were rapidly attained, and the brain penetration factor was close to 5% in the absence and presence of PRO. In conclusion, PRO has no effec...

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Bibliografiske detaljer
Main Authors: Marchand, Sandrine, Forsell, Anna, Chenel, Marylore, Comets, Emmanuelle, Lamarche, Isabelle, Couet, William
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2006
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346768/
https://ncbi.nlm.nih.gov/pubmed/16377715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.1.371-373.2006
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