Cyclosporin A enhances colchicine-induced apoptosis in rat cerebellar granule neurons

1. Cyclosporin A (CsA, 1–50 μM), an immunosuppressive drug with known neurotoxic effects, did not decrease the viability of primary cultures of rat cerebellar granule neurons (CGN) or induce apoptotic features. However, CsA specifically enhanced the cytotoxicity and apoptosis induced by colchicine (...

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Bibliografiske detaljer
Main Authors: Canudas, Anna Maria, Jordà, Elvira G, Verdaguer, Ester, Jiménez, Andrés, Sureda, Francesc Xavier, Rimbau, Víctor, Camins, Antoni, Pallàs, Mercè
Format: Artigo
Sprog:Inglês
Udgivet: 2004
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Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1574246/
https://ncbi.nlm.nih.gov/pubmed/14976124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705664
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