Kainic acid-induced neuronal cell death in cerebellar granule cells is not prevented by caspase inhibitors

1. We examined the role of non-NMDA receptors in kainic acid (KA)-induced apoptosis in cultures of rat cerebellar granule cells (CGCs). KA (1 – 500 μM) induced cell death in a concentration-dependent manner, which was prevented by NBQX and GYKI 52466, non-NMDA receptor antagonists. Moreover, AMPA bl...

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Main Authors: Verdaguer, Ester, García-Jordà, Elvira, Jiménez, Andrés, Stranges, Alessandra, Sureda, Francesc X, Canudas, Anna M, Escubedo, Elena, Camarasa, Jordi, Pallàs, Mercè, Camins, Antoni
Format: Artigo
Language:Inglês
Published: 2002
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573245/
https://ncbi.nlm.nih.gov/pubmed/11877339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704581
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