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Bupivacaine effects on hKv1.5 channels are dependent on extracellular pH
1. Bupivacaine-induced cardiotoxicity increases in hypoxic and acidotic conditions. We have analysed the effects of R(+)bupivacaine on hKv1.5 channels stably expressed in Ltk(−) cells using the whole-cell patch-clamp technique, at three different extracellular pH (pH(o)), 6.5, 7.4 and 10.0. 2. Acidi...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1572951/ https://ncbi.nlm.nih.gov/pubmed/11564654 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704251 |
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