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Effect of descarboethoxyloratadine, the major metabolite of loratadine, on the human cardiac potassium channel Kv1.5
The effects of descarboethoxyloratadine (DCL), the major metabolite of loratadine, were studied on a human cardiac K(+) channel (hKv1.5) cloned from human ventricle and stably expressed in a mouse cell line by means of the patch-clamp technique. DCL (1–100 μM) inhibited hKv1.5 current in a concentra...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1565020/ https://ncbi.nlm.nih.gov/pubmed/9384491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701468 |
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