Spironolactone and its main metabolite canrenoic acid block hKv1.5, Kv4.3 and Kv7.1+minK channels

1. Both spironolactone (SP) and its main metabolite, canrenoic acid (CA), prolong cardiac action potential duration and decrease the Kv11.1 (HERG) current. We examined the effects of SP and CA on cardiac hKv1.5, Kv4.3 and Kv7.1+minK channels that generate the human I(Kur), I(to1) and I(Ks), which co...

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Hauptverfasser: Gómez, Ricardo, Núñez, Lucía, Caballero, Ricardo, Vaquero, Miguel, Tamargo, Juan, Delpón, Eva
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2005
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Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1576250/
https://ncbi.nlm.nih.gov/pubmed/15980874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706302
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