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Bupivacaine effects on hKv1.5 channels are dependent on extracellular pH

1. Bupivacaine-induced cardiotoxicity increases in hypoxic and acidotic conditions. We have analysed the effects of R(+)bupivacaine on hKv1.5 channels stably expressed in Ltk(−) cells using the whole-cell patch-clamp technique, at three different extracellular pH (pH(o)), 6.5, 7.4 and 10.0. 2. Acidi...

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Main Authors: Longobardo, M, González, T, Caballero, R, Delpón, E, Tamargo, J, Valenzuela, C
格式: Artigo
語言:Inglês
出版: 2001
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572951/
https://ncbi.nlm.nih.gov/pubmed/11564654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704251
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