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Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers.
Stereoselective drug-channel interactions may help to elucidate the molecular basis of voltage-gated potassium channel block by local anesthetic drugs. We studied the effects of the enantiomers of bupivacaine on a cloned human cardiac potassium channel (hKv1.5). This channel was stably expressed in...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The Biophysical Society
1995
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1236266/ https://ncbi.nlm.nih.gov/pubmed/8527655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0006-3495(95)79914-3 |
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