Effect of furanocoumarin derivatives in grapefruit juice on the uptake of vinblastine by Caco-2 cells and on the activity of cytochrome P450 3A4

1. The presence of inhibitors of drug efflux transporters, such as P-glycoprotein (P-gp), in grapefruit juice (GFJ) was confirmed based on the uptake of [(3)H]-vinblastine (VBL) by Caco-2 cells. 2. The uptake of [(3)H]-VBL by Caco-2 cells was significantly increased by the ethyl acetate extract of G...

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Detaylı Bibliyografya
Asıl Yazarlar: Ohnishi, Ayako, Matsuo, Hirotami, Yamada, Shiho, Takanaga, Hitomi, Morimoto, Satoshi, Shoyama, Yukihiro, Ohtani, Hisakazu, Sawada, Yasufumi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2000
Konular:
Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572193/
https://ncbi.nlm.nih.gov/pubmed/10903978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703433
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