Effect of furanocoumarin derivatives in grapefruit juice on the uptake of vinblastine by Caco-2 cells and on the activity of cytochrome P450 3A4

1. The presence of inhibitors of drug efflux transporters, such as P-glycoprotein (P-gp), in grapefruit juice (GFJ) was confirmed based on the uptake of [(3)H]-vinblastine (VBL) by Caco-2 cells. 2. The uptake of [(3)H]-VBL by Caco-2 cells was significantly increased by the ethyl acetate extract of G...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Ohnishi, Ayako, Matsuo, Hirotami, Yamada, Shiho, Takanaga, Hitomi, Morimoto, Satoshi, Shoyama, Yukihiro, Ohtani, Hisakazu, Sawada, Yasufumi
פורמט: Artigo
שפה:Inglês
יצא לאור: 2000
נושאים:
Papers
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572193/
https://ncbi.nlm.nih.gov/pubmed/10903978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703433
תגים: הוספת תג
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!

פריטים דומים