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Rapid Quantitation of Furanocoumarins and Flavonoids in Grapefruit Juice using Ultra Performance Liquid Chromatography

INTRODUCTION: Grapefruit juice can increase or decrease the systemic exposure of myriad oral medications, leading to untoward effects or reduced efficacy. Furanocoumarins in grapefruit juice have been established as inhibitors of cytochrome P450 3A (CYP3A)-mediated metabolism and P-glycoprotein (P-g...

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Detalhes bibliográficos
Main Authors: VanderMolen, Karen M., Cech, Nadja B., Paine, Mary F., Oberlies, Nicholas H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855432/
https://ncbi.nlm.nih.gov/pubmed/23780830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pca.2449
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