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An H-bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism of nicotinic receptors

The molecular mechanisms of nicotinic receptor activation are still largely unknown. The crystallographic structure of the acetylcholine binding protein (AChBP) reveals a single H-bond between two different acetylcholine binding loops. Within these homologous loops we systematically introduced α4 re...

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Bibliografiske detaljer
Main Authors: Grutter, Thomas, Prado de Carvalho, Lia, Le Novère, Nicolas, Corringer, Pierre Jean, Edelstein, Stuart, Changeux, Jean-Pierre
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC156069/
https://ncbi.nlm.nih.gov/pubmed/12727867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg197
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