BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer

BRIT1, initially identified as an hTERT repressor, has additional functions at DNA damage checkpoints. Here, we demonstrate that BRIT1 formed nuclear foci minutes after irradiation. The foci of BRIT1 colocalized with 53BP1, MDC1, NBS1, ATM, RPA, and ATR. BRIT1 was required for activation of these el...

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Bibliografiset tiedot
Päätekijät: Rai, Rekha, Dai, Hui, Multani, Asha S., Li, Kaiyi, Chin, Koei, Gray, Joe, Lahad, John P., Liang, Jiyong, Mills, Gordon B., Meric-Bernstam, Funda, Lin, Shiaw-Yih
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2006
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1557410/
https://ncbi.nlm.nih.gov/pubmed/16872911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2006.07.002
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