BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer

BRIT1, initially identified as an hTERT repressor, has additional functions at DNA damage checkpoints. Here, we demonstrate that BRIT1 formed nuclear foci minutes after irradiation. The foci of BRIT1 colocalized with 53BP1, MDC1, NBS1, ATM, RPA, and ATR. BRIT1 was required for activation of these el...

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Autores principales: Rai, Rekha, Dai, Hui, Multani, Asha S., Li, Kaiyi, Chin, Koei, Gray, Joe, Lahad, John P., Liang, Jiyong, Mills, Gordon B., Meric-Bernstam, Funda, Lin, Shiaw-Yih
Formato: Artigo
Lenguaje:Inglês
Publicado: 2006
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1557410/
https://ncbi.nlm.nih.gov/pubmed/16872911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2006.07.002
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