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BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1–Chk1 pathway, implicating checkpoint dysfunction in microcephaly
BRIT1 [BRCT-repeat inhibitor of hTERT expression], a repressor of human telomerase function, is implicated in cellular immortalization. Here, we find that BRIT1 acts as a regulator of both the intra-S and G(2)/M checkpoints. When BRIT1 expression is depleted, cells lose the ionizing radiation (IR)-i...
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| Päätekijät: | , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
National Academy of Sciences
2005
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1257745/ https://ncbi.nlm.nih.gov/pubmed/16217032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507722102 |
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