BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1–Chk1 pathway, implicating checkpoint dysfunction in microcephaly

BRIT1 [BRCT-repeat inhibitor of hTERT expression], a repressor of human telomerase function, is implicated in cellular immortalization. Here, we find that BRIT1 acts as a regulator of both the intra-S and G(2)/M checkpoints. When BRIT1 expression is depleted, cells lose the ionizing radiation (IR)-i...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lin, Shiaw-Yih, Rai, Rekha, Li, Kaiyi, Xu, Zhi-Xiang, Elledge, Stephen J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2005
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1257745/
https://ncbi.nlm.nih.gov/pubmed/16217032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507722102
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