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Mcph1/Brit1 deficiency promotes genomic instability and tumor formation in a mouse model

MCPH1, also known as BRIT1, has recently been identified as a novel key regulatory gene of the DNA damage response pathway. MCPH1 is located on human chromosome 8p23.1, where human cancers frequently show loss of heterozygosity. As such, MCPH1 is aberrantly expressed in many malignancies, including...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Oncogene
المؤلفون الرئيسيون: Liang, Yulong, Gao, Hong, Lin, Shiaw-Yih, Goss, John A., Du, Chunying, Li, Kaiyi
التنسيق: Artigo
اللغة:Inglês
منشور في: 2014
الموضوعات:
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC4417661/
https://ncbi.nlm.nih.gov/pubmed/25362854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.367
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