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Lethal mutagenesis of HIV with mutagenic nucleoside analogs

The human immunodeficiency virus (HIV) replicates its genome and mutates at exceptionally high rates. As a result, the virus is able to evade immunological and chemical antiviral agents. We tested the hypothesis that a further increase in the mutation rate by promutagenic nucleoside analogs would ab...

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Detalhes bibliográficos
Main Authors: Loeb, Lawrence A., Essigmann, John M., Kazazi, Farhad, Zhang, Jue, Rose, Karl D., Mullins, James I.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC15492/
https://ncbi.nlm.nih.gov/pubmed/9990051
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