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Lethal mutagenesis of HIV with mutagenic nucleoside analogs

The human immunodeficiency virus (HIV) replicates its genome and mutates at exceptionally high rates. As a result, the virus is able to evade immunological and chemical antiviral agents. We tested the hypothesis that a further increase in the mutation rate by promutagenic nucleoside analogs would ab...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Loeb, Lawrence A., Essigmann, John M., Kazazi, Farhad, Zhang, Jue, Rose, Karl D., Mullins, James I.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15492/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9990051/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.4.1492
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