Mutation of HIV-1 Genomes in a Clinical Population Treated with the Mutagenic Nucleoside KP1461

The deoxycytidine analog KP1212, and its prodrug KP1461, are prototypes of a new class of antiretroviral drugs designed to increase viral mutation rates, with the goal of eventually causing the collapse of the viral population. Here we present an extensive analysis of viral sequences from HIV-1 infe...

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Hoofdauteurs: Mullins, James I., Heath, Laura, Hughes, James P., Kicha, Jessica, Styrchak, Sheila, Wong, Kim G., Rao, Ushnal, Hansen, Alexis, Harris, Kevin S., Laurent, Jean-Pierre, Li, Deyu, Simpson, Jeffrey H., Essigmann, John M., Loeb, Lawrence A., Parkins, Jeffrey
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2011
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021505/
https://ncbi.nlm.nih.gov/pubmed/21264288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015135
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