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Lethal Mutagenesis: targeting the mutator phenotype in cancer
The evolution of cancer and RNA viruses share many similarities. Both exploit high levels of genotypic diversity to enable extensive phenotypic plasticity and thereby facilitate rapid adaptation. In order to accumulate large numbers of mutations, we have proposed that cancers express a mutator pheno...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3256989/ https://ncbi.nlm.nih.gov/pubmed/20934515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcancer.2010.10.005 |
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