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Mutational Heterogeneity in Human Cancers: Origin and Consequences

Cancer recapitulates Darwinian evolution. Mutations acquired during life that provide cells with a growth or survival advantage will preferentially multiply to form a tumor. As a result of The Cancer Genome Atlas project we have now gathered detailed information on the nucleotide sequence changes in...

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Autores principales: Salk, Jesse J., Fox, Edward J., Loeb, Lawrence A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375045/
https://ncbi.nlm.nih.gov/pubmed/19743960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-pathol-121808-102113
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