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The Mutator Phenotype in Cancer: Molecular Mechanisms and Targeting Strategies

Normal human cells replicate their DNA with exceptional accuracy. It has been estimated that approximately one error occurs during DNA replication for each 10(9) to 10(10) nucleotides polymerized. In contrast, malignant cells exhibit multiple chromosomal abnormalities and contain tens of thousands o...

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Bibliografski detalji
Glavni autori: Prindle, Marc J., Fox, Edward J., Loeb, Lawrence A.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073693/
https://ncbi.nlm.nih.gov/pubmed/20840072
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