Divergent synthetic nucleotide motif recognition pattern: design and development of potent immunomodulatory oligodeoxyribonucleotide agents with distinct cytokine induction profiles

Unmethylated CpG dinucleotides present within certain specific sequence contexts in bacterial and synthetic DNA stimulate innate immune responses and induce cytokine secretion. Recently, we showed that CpG DNAs containing two 5′-ends, immunomers, are more potent in both regards. In this study, we sh...

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書誌詳細

出版年:	Nucleic Acids Res
主要な著者:	Kandimalla, Ekambar R., Bhagat, Lakshmi, Wang, Daqing, Yu, Dong, Zhu, Fu-Gang, Tang, Jimmy, Wang, Hui, Huang, Ping, Zhang, Ruiwen, Agrawal, Sudhir
フォーマット:	Artigo
言語:	Inglês
出版事項:	Oxford University Press 2003
主題:	Articles
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC154229/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12711684/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg343
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