Divergent synthetic nucleotide motif recognition pattern: design and development of potent immunomodulatory oligodeoxyribonucleotide agents with distinct cytokine induction profiles

Unmethylated CpG dinucleotides present within certain specific sequence contexts in bacterial and synthetic DNA stimulate innate immune responses and induce cytokine secretion. Recently, we showed that CpG DNAs containing two 5′-ends, immunomers, are more potent in both regards. In this study, we sh...

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Detalhes bibliográficos
Main Authors: Kandimalla, Ekambar R., Bhagat, Lakshmi, Wang, Daqing, Yu, Dong, Zhu, Fu-Gang, Tang, Jimmy, Wang, Hui, Huang, Ping, Zhang, Ruiwen, Agrawal, Sudhir
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2003
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC154229/
https://ncbi.nlm.nih.gov/pubmed/12711684
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