Divergent synthetic nucleotide motif recognition pattern: design and development of potent immunomodulatory oligodeoxyribonucleotide agents with distinct cytokine induction profiles

Unmethylated CpG dinucleotides present within certain specific sequence contexts in bacterial and synthetic DNA stimulate innate immune responses and induce cytokine secretion. Recently, we showed that CpG DNAs containing two 5′-ends, immunomers, are more potent in both regards. In this study, we sh...

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Hauptverfasser: Kandimalla, Ekambar R., Bhagat, Lakshmi, Wang, Daqing, Yu, Dong, Zhu, Fu-Gang, Tang, Jimmy, Wang, Hui, Huang, Ping, Zhang, Ruiwen, Agrawal, Sudhir
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2003
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC154229/
https://ncbi.nlm.nih.gov/pubmed/12711684
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