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Immunostimulatory properties of phosphorothioate CpG DNA containing both 3′–5′- and 2′–5′-internucleotide linkages

Synthetic oligodeoxyribonucleotides containing CpG-dinucleotides (CpG DNA) in specific sequence contexts activate the vertebrate immune system. We have examined the effect of 3′-deoxy-2′–5′-ribonucleoside (3′-deoxynucleoside) incorporation into CpG DNA on the immunostimulatory activity. Incorporatio...

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Detalles Bibliográficos
Main Authors: Yu, Dong, Kandimalla, Ekambar R., Zhao, Qiuyan, Cong, Yanping, Agrawal, Sudhir
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2002
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC101845/
https://ncbi.nlm.nih.gov/pubmed/11917022
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