A dinucleotide motif in oligonucleotides shows potent immunomodulatory activity and overrides species-specific recognition observed with CpG motif

Podobne zapisy

• ‘Immunomers’—novel 3′–3′-linked CpG oligodeoxyribonucleotides as potent immunomodulatory agents
  od: Yu, Dong, i wsp.
  Wydane: (2002)
• Immunomodulatory oligonucleotides containing a cytosine-phosphate-2′-deoxy-7-deazaguanosine motif as potent Toll-like receptor 9 agonists
  od: Kandimalla, Ekambar R., i wsp.
  Wydane: (2005)
• Divergent synthetic nucleotide motif recognition pattern: design and development of potent immunomodulatory oligodeoxyribonucleotide agents with distinct cytokine induction profiles
  od: Kandimalla, Ekambar R., i wsp.
  Wydane: (2003)
• Immune-Stimulatory Dinucleotide at the 5′-End of Oligodeoxynucleotides Is Critical for TLR9-Mediated Immune Responses
  od: Putta, Mallikarjuna R., i wsp.
  Wydane: (2013)
• Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9
  od: Kandimalla, Ekambar R., i wsp.
  Wydane: (2013)