A dinucleotide motif in oligonucleotides shows potent immunomodulatory activity and overrides species-specific recognition observed with CpG motif

Bacterial and synthetic DNAs containing CpG dinucleotides in specific sequence contexts activate the vertebrate immune system through Toll-like receptor 9 (TLR9). In the present study, we used a synthetic nucleoside with a bicyclic heterobase [1-(2′-deoxy-β-d-ribofuranosyl)-2-oxo-7-deaza-8-methyl-pu...

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Detalhes bibliográficos
Main Authors: Kandimalla, Ekambar R., Bhagat, Lakshmi, Zhu, Fu-Gang, Yu, Dong, Cong, Yan-Ping, Wang, Daqing, Tang, Jimmy X., Tang, Jin-Yan, Knetter, Cathrine F., Lien, Egil, Agrawal, Sudhir
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC283587/
https://ncbi.nlm.nih.gov/pubmed/14610275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2335947100
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