Site-specific mutagenesis by triple helix-forming oligonucleotides containing a reactive nucleoside analog

The specific recognition of homopurine–homo pyrimidine regions in duplex DNA by triplex-forming oligonucleotides (TFOs) provides an attractive strategy for genetic manipulation. Alkylation of nucleobases with functionalized TFOs would have the potential for site-directed mutagenesis. Recently, we de...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Nagatsugi, Fumi, Sasaki, Shigeki, Miller, Paul S., Seidman, Michael M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2003
Assuntos:	NAR Methods Online
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152885/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12626730/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gng031
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!