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Triglyceride accumulation protects against fatty acid-induced lipotoxicity

Excess lipid accumulation in non-adipose tissues is associated with insulin resistance, pancreatic β-cell apoptosis and heart failure. Here, we demonstrate in cultured cells that the relative toxicity of two common dietary long chain fatty acids is related to channeling of these lipids to distinct c...

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Bibliografiske detaljer
Main Authors: Listenberger, Laura L., Han, Xianlin, Lewis, Sarah E., Cases, Sylvaine, Farese, Robert V., Ory, Daniel S., Schaffer, Jean E.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC152249/
https://ncbi.nlm.nih.gov/pubmed/12629214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0630588100
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