Enhanced growth of tumors in SPARC null mice is associated with changes in the ECM

SPARC, a 32-kDa glycoprotein, participates in the regulation of morphogenesis and cellular differentiation through its modulation of cell-matrix interactions. Major functions defined for SPARC in vitro are de-adhesion and antiproliferation. In vivo, SPARC is restricted in its expression to remodelin...

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Pubblicato in:	J Clin Invest
Autori principali:	Brekken, Rolf A., Puolakkainen, Pauli, Graves, David C., Workman, Gail, Lubkin, Sharon R., Sage, E. Helene
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 2003
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151926/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12588887/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI16804
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