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Enhanced growth of tumors in SPARC null mice is associated with changes in the ECM

SPARC, a 32-kDa glycoprotein, participates in the regulation of morphogenesis and cellular differentiation through its modulation of cell-matrix interactions. Major functions defined for SPARC in vitro are de-adhesion and antiproliferation. In vivo, SPARC is restricted in its expression to remodelin...

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Udgivet i:J Clin Invest
Principais autores: Brekken, Rolf A., Puolakkainen, Pauli, Graves, David C., Workman, Gail, Lubkin, Sharon R., Sage, E. Helene
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2003
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151926/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12588887/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI16804
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