Enhanced growth of tumors in SPARC null mice is associated with changes in the ECM

SPARC, a 32-kDa glycoprotein, participates in the regulation of morphogenesis and cellular differentiation through its modulation of cell-matrix interactions. Major functions defined for SPARC in vitro are de-adhesion and antiproliferation. In vivo, SPARC is restricted in its expression to remodelin...

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Hlavní autoři: Brekken, Rolf A., Puolakkainen, Pauli, Graves, David C., Workman, Gail, Lubkin, Sharon R., Sage, E. Helene
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2003
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC151926/
https://ncbi.nlm.nih.gov/pubmed/12588887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316804
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