Misfolded proteinase K–resistant hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α-synucleinopathies

The pathological modifications of α-synuclein (αS) in Parkinson disease and related diseases are poorly understood. We have detected misfolded αS in situ based on the proteinase K resistance (PK resistance) of αS fibrils, and using specific antibodies against S129-phosphorylated αS as well as oxidiz...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Neumann, Manuela, Kahle, Philipp J., Giasson, Benoit I., Ozmen, Laurence, Borroni, Edilio, Spooren, Will, Müller, Veronika, Odoy, Sabine, Fujiwara, Hideo, Hasegawa, Masato, Iwatsubo, Takeshi, Trojanowski, John Q., Kretzschmar, Hans A., Haass, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2002
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC151810/
https://ncbi.nlm.nih.gov/pubmed/12438441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI15777
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados