Selective Insolubility of α-Synuclein in Human Lewy Body Diseases Is Recapitulated in a Transgenic Mouse Model

α-Synuclein (α-SYN) is deposited in intraneuronal cytoplasmic inclusions (Lewy bodies, LBs) characteristic for Parkinson’s disease (PD) and LB dementias. α-SYN forms LB-like fibrils in vitro, in contrast to its homologue β-SYN. Here we have investigated the solubility of SYNs in human LB diseases an...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Kahle, Philipp J., Neumann, Manuela, Ozmen, Laurence, Müller, Veronika, Odoy, Sabine, Okamoto, Noriko, Jacobsen, Helmut, Iwatsubo, Takeshi, Trojanowski, John Q., Takahashi, Hitoshi, Wakabayashi, Koichi, Bogdanovic, Nenad, Riederer, Peter, Kretzschmar, Hans A., Haass, Christian
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Investigative Pathology 2001
Aiheet:
Regular Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850592/
https://ncbi.nlm.nih.gov/pubmed/11733371
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