Selective Insolubility of α-Synuclein in Human Lewy Body Diseases Is Recapitulated in a Transgenic Mouse Model

α-Synuclein (α-SYN) is deposited in intraneuronal cytoplasmic inclusions (Lewy bodies, LBs) characteristic for Parkinson’s disease (PD) and LB dementias. α-SYN forms LB-like fibrils in vitro, in contrast to its homologue β-SYN. Here we have investigated the solubility of SYNs in human LB diseases an...

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Detalhes bibliográficos
Main Authors: Kahle, Philipp J., Neumann, Manuela, Ozmen, Laurence, Müller, Veronika, Odoy, Sabine, Okamoto, Noriko, Jacobsen, Helmut, Iwatsubo, Takeshi, Trojanowski, John Q., Takahashi, Hitoshi, Wakabayashi, Koichi, Bogdanovic, Nenad, Riederer, Peter, Kretzschmar, Hans A., Haass, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2001
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850592/
https://ncbi.nlm.nih.gov/pubmed/11733371
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