Increased ABCA1 activity protects against atherosclerosis

The ABC transporter ABCA1 plays a key role in the first steps of the reverse cholesterol transport pathway by mediating lipid efflux from macrophages. Previously, it was demonstrated that human ABCA1 overexpression in vivo in transgenic mice results in a mild elevation of plasma HDL levels and incre...

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Auteurs principaux: Singaraja, Roshni R., Fievet, Catherine, Castro, Graciela, James, Erick R., Hennuyer, Nathalie, Clee, Susanne M., Bissada, Nagat, Choy, Jonathan C., Fruchart, Jean-Charles, McManus, Bruce M., Staels, Bart, Hayden, Michael R.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2002
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC151034/
https://ncbi.nlm.nih.gov/pubmed/12093886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI15748
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