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Mechanisms by which IκB proteins control NF-κB activity

The biological activity of the transcription factor NF-κB is differentially controlled by three IκB proteins, IκBα, IκBβ, and IκBɛ. We have examined the molecular basis for the differential inhibitory strengths of IκB proteins by constructing hybrid IκBs and found that the first ankyrin repeat of Iκ...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Simeonidis, Simos, Stauber, Deborah, Chen, Guoying, Hendrickson, Wayne A., Thanos, Dimitris
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15091/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9874770/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.1.49
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