Regulation of the NK-1 receptor gene expression in human macrophage cells via an NF-κB site on its promoter

We report here that human monocytic/macrophage THP-1 cells express the neurokinin 1 receptor (NK-1R), and that exposure of these cells to the proinflammatory cytokine IL-1β increased the expression of the NK-1R gene at the mRNA and protein levels. Because IL-1β function involves nuclear factor κB (N...

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Detalhes bibliográficos
Main Authors: Simeonidis, Simos, Castagliuolo, Ignazio, Pan, Amy, Liu, Jennifer, Wang, Chi-Chi, Mykoniatis, Andreas, Pasha, Asia, Valenick, Leyla, Sougioultzis, Stavros, Zhao, Dezheng, Pothoulakis, Charalabos
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC151448/
https://ncbi.nlm.nih.gov/pubmed/12594338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0530112100
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