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Mechanisms by which IκB proteins control NF-κB activity

The biological activity of the transcription factor NF-κB is differentially controlled by three IκB proteins, IκBα, IκBβ, and IκBɛ. We have examined the molecular basis for the differential inhibitory strengths of IκB proteins by constructing hybrid IκBs and found that the first ankyrin repeat of Iκ...

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主要な著者: Simeonidis, Simos, Stauber, Deborah, Chen, Guoying, Hendrickson, Wayne A., Thanos, Dimitris
フォーマット: Artigo
言語:Inglês
出版事項: The National Academy of Sciences 1999
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC15091/
https://ncbi.nlm.nih.gov/pubmed/9874770
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