Negative Regulation of BRCA1 Gene Expression by HMGA1 Proteins Accounts for the Reduced BRCA1 Protein Levels in Sporadic Breast Carcinoma

A drastic reduction in BRCA1 gene expression is a characteristic feature of aggressive sporadic breast carcinoma. However, the mechanisms underlying BRCA1 downregulation in breast cancer are not well understood. Here we report that both in vitro and in vivo HMGA1b protein binds to and inhibits the a...

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Autors principals: Baldassarre, Gustavo, Battista, Sabrina, Belletti, Barbara, Thakur, Sanjay, Pentimalli, Francesca, Trapasso, Francesco, Fedele, Monica, Pierantoni, Giovanna, Croce, Carlo M., Fusco, Alfredo
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
Matèries:
Transcriptional Regulation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC150734/
https://ncbi.nlm.nih.gov/pubmed/12640109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.7.2225-2238.2003
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