Negative Regulation of BRCA1 Gene Expression by HMGA1 Proteins Accounts for the Reduced BRCA1 Protein Levels in Sporadic Breast Carcinoma

A drastic reduction in BRCA1 gene expression is a characteristic feature of aggressive sporadic breast carcinoma. However, the mechanisms underlying BRCA1 downregulation in breast cancer are not well understood. Here we report that both in vitro and in vivo HMGA1b protein binds to and inhibits the a...

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Bibliografische gegevens

Gepubliceerd in:	Mol Cell Biol
Hoofdauteurs:	Baldassarre, Gustavo, Battista, Sabrina, Belletti, Barbara, Thakur, Sanjay, Pentimalli, Francesca, Trapasso, Francesco, Fedele, Monica, Pierantoni, Giovanna, Croce, Carlo M., Fusco, Alfredo
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Taylor & Francis 2003
Onderwerpen:	Transcriptional Regulation
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC150734/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12640109/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.7.2225-2238.2003
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