Negative Regulation of BRCA1 Gene Expression by HMGA1 Proteins Accounts for the Reduced BRCA1 Protein Levels in Sporadic Breast Carcinoma

A drastic reduction in BRCA1 gene expression is a characteristic feature of aggressive sporadic breast carcinoma. However, the mechanisms underlying BRCA1 downregulation in breast cancer are not well understood. Here we report that both in vitro and in vivo HMGA1b protein binds to and inhibits the a...

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Bibliographic Details
Main Authors: Baldassarre, Gustavo, Battista, Sabrina, Belletti, Barbara, Thakur, Sanjay, Pentimalli, Francesca, Trapasso, Francesco, Fedele, Monica, Pierantoni, Giovanna, Croce, Carlo M., Fusco, Alfredo
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Transcriptional Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC150734/
https://ncbi.nlm.nih.gov/pubmed/12640109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.7.2225-2238.2003
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