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Negative Regulation of BRCA1 Gene Expression by HMGA1 Proteins Accounts for the Reduced BRCA1 Protein Levels in Sporadic Breast Carcinoma

A drastic reduction in BRCA1 gene expression is a characteristic feature of aggressive sporadic breast carcinoma. However, the mechanisms underlying BRCA1 downregulation in breast cancer are not well understood. Here we report that both in vitro and in vivo HMGA1b protein binds to and inhibits the a...

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Udgivet i:Mol Cell Biol
Principais autores: Baldassarre, Gustavo, Battista, Sabrina, Belletti, Barbara, Thakur, Sanjay, Pentimalli, Francesca, Trapasso, Francesco, Fedele, Monica, Pierantoni, Giovanna, Croce, Carlo M., Fusco, Alfredo
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2003
Fag:
Transcriptional Regulation
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC150734/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12640109/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.7.2225-2238.2003
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