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Dissecting the Contribution of p16(INK4A) and the Rb Family to the Ras Transformed Phenotype
Although oncogenic Ras commonly contributes to the development of cancer, in normal primary cells it induces cell cycle arrest rather than transformation. Here we analyze the additional genetic changes required for Ras to promote cell cycle progression rather than arrest. We show that loss of p53 is...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC150721/ https://ncbi.nlm.nih.gov/pubmed/12640134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.7.2530-2542.2003 |
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