Blocking CHK1 Expression Induces Apoptosis and Abrogates the G2 Checkpoint Mechanism

Checkpoint kinase 1 (Chk1) is a checkpoint gene that is activated after DNA damage. It phosphorylates and inactivates the Cdc2 activating phosphatase Cdc25C. This in turn inactivates Cdc2, which leads to G2/M arrest. We report that blocking Chk1 expression by antisense or ribozymes in mammalian cell...

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Detalhes bibliográficos
Main Authors: Luo, Yan, Rockow-Magnone, Shayna K, Kroeger, Paul E, Frost, Leigh, Chen, Zehan, Han, Edward K-H, Ng, Shi-Chung, Simmer, Robert L, Giranda, Vincent L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2001
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1506209/
https://ncbi.nlm.nih.gov/pubmed/11687952
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