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Abrogation of the Chk1-Pds1 Checkpoint Leads to Tolerance of Persistent Single-Strand Breaks in Saccharomyces cerevisiae
In budding yeast, Apn1, Apn2, Tpp1, and Rad1/Rad10 are important enzymes in the removal of spontaneous DNA lesions. apn1 apn2 rad1 yeast are inviable due to accumulation of abasic sites and strand breaks with 3′ blocking lesions. We found that tpp1 apn1 rad1 yeast exhibited slow growth but frequentl...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Genetics Society of America
2005
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1449591/ https://ncbi.nlm.nih.gov/pubmed/15687272 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.104.035931 |
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