A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint

We reported previously that when cells are arrested in S phase, a subset of p53 target genes fails to be strongly induced despite the presence of high levels of p53. When DNA replication is inhibited, reduced p21 mRNA accumulation is correlated with a marked reduction in transcription elongation. He...

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Detalhes bibliográficos
Main Authors: Beckerman, Rachel, Donner, Aaron J., Mattia, Melissa, Peart, Melissa J., Manley, James L., Espinosa, Joaquin M., Prives, Carol
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2009
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701578/
https://ncbi.nlm.nih.gov/pubmed/19487575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1795709
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